From the A3 Napoli-Salerno highway, exit at Castellammare di Stabia; continue along the SS145 state road following directions for Sorrento. After Vico Equense you will reach Seiano. Continue for about 2km more and you will see the hotel on the left.
From Naples central station (Piazza Garibaldi), take the Naples-Sorrento train on the local Circumvesuviana line, and get off at SEIANO. Using the same ticket the hotel can be reached by public bus heading towards Sorrento.
From Naples Capodichino airport, take a bus or taxi to Naples central station, and from there take the local Circumvesuviana train. Alternatively you could book a private transfer.